Publications

23.
Ang, E.; Chang, J. S.; Huang, W.-E.; Ullrich, S.; Vinogradov, A. A.; Suga, H.;
“Elucidating leader peptide−enzyme dynamics in lactazole biosynthesis using mRNA display”
J. Am. Chem. Soc., 2026, 148, 2890–2895.
22.
Ullrich, S.;*
“Shaping the future of constrained peptides and compact proteins in drug discovery”
Aust. J. Chem., 2025, 78, CH25122.
21.
Ullrich, S.;‡ Philippe, G. J.-B.;‡ Li, C. Y.;‡ Suga, H;
“Rational design and selection of next-generation cyclotide drugs using the knotted cyclic peptide scaffold MCoTI-II”
Aust. J. Chem., 2025, 78, CH25086.
20.
Ullrich, S.; Nitsche, C;
“Synthesis of bicyclic peptides using cyanopyridine-aminothiol click chemistry”
In: Methods in Molecular Biology; Springer, New York, USA, 2025, Ch. 2, 13–25.
19.
He, J.; Illingworth, H.; Ullrich, S.; Ghosh, P.; Ton, J.; Jackson, C. J.; Nitsche, C;
“Synthesis, screening and validation of cysteine-reactive fragments as Chikungunya virus protease inhibitors”
Bioorg. Med. Chem. Lett., 2025, 122, 130176.
18.
Ullrich, S.;‡ Kumaresan, S.;‡ Rahman, M. G.; Panda, B.; Morewood, R.; Nitsche, C;
“Assembling branched and macrocyclic peptides on proteins”
Chem. Commun., 2025, 61, 3009–3012.
17.
Davies, L. J.; Ghosh, P.; Siryer, S; Ullrich, S.; Nitsche, C;
“Peptide–bismuth tricycles: Maximizing stability by constraint”
Chem. Eur. J., 2025, 31, e202500064.
16.
Ullrich, S.; Nitsche, C;
“4-Fluoro-2,6-dicyanopyridine”
In: Encyclopedia of Reagents for Organic Synthesis; Wiley, Hoboken, USA, 2025.
15.
Ullrich, S.;*, ‡ Panda, B.;‡ Somathilake, U.; Lawes, D. J.; Nitsche, C.;*
“Non-symmetric cysteine stapling in native peptides and proteins”
Chem. Commun., 2025, 61, 933–936.
14.
Ullrich, S.;‡ Ghosh, P.;‡ Shang, M.; Siryer, S.; Kumaresan, S.; Panda, B.; Davies, L. J.; Somathilake, U.; Patel, A. P.; Nitsche, C;
“Synthesis and stability studies of constrained peptide–antimony bicycles”
Aust. J. Chem., 2024, 77, CH24094.
13.
Ullrich, S.;‡ Somathilake, U.;‡ Shang, M.; Nitsche, C;
“Phage-encoded bismuth bicycles enable instant access to targeted bioactive peptides”
Commun. Chem., 2024, 7, 143.
12.
Harrison, K.; Carlos, P.; Ullrich, S.; Aggarwal, A.; Johansen-Leete, J.; Sasi, V. M.; Barter, I.; Maxwell, J.; Bedding, M.; Larance, M.; Turville, S.; Norman, A.; Jackson, C.; Payne, R. J;
“Exploiting hydrophobic amino acid scanning to develop cyclic peptide inhibitors of the SARS-CoV-2 main protease with antiviral activity”
Chem. Eur. J., 2024, 30, e202401606.
11.
Ullrich, S.; Nitsche, C;
“A RaPID response to SARS-CoV-2”
Isr. J. Chem., 2024, 64, e202300170.
10.
Ullrich, S.;* Nitsche, C.;*
“Bicyclic peptides: Paving the road for therapeutics of the future”
Pept. Sci., 2024, 116, e24326.
9.
Ekanayake, K. B.; Mahawaththa, M. C.; Qianzhu, H.; Abdelkader, E. H.; George, J.; Ullrich, S.; Murphy, R. B.; Fry, S. E.; Johansen-Leete, J; Payne, R. J.; Nitsche, C.; Huber, T.; Otting, G;
“Probing ligand binding sites on large proteins by nuclear magnetic resonance spectroscopy of genetically encoded non-canonical amino acids”
J. Med. Chem., 2023, 66, 5289–5304.
8.
Sasi, V. M.;‡ Ullrich, S.;‡ Ton, J.; Fry, S.E; Johansen-Leete, J.; Payne, R. J.; Nitsche, C.; Jackson, C. J;
“Predicting antiviral resistance mutations in SARS-CoV-2 main protease with computational and experimental screening”
Biochemistry, 2022, 61, 2495–2505.
7.
Ullrich, S.; Nitsche, C;
“SARS-CoV-2 papain-like protease: Structure, function and inhibition”
ChemBioChem, 2022, 23, e202200327.
6.
Mekkattu Tharayil, S.; Mahawaththa, M. C.; Feintuch, A.; Maleckis, A.; Ullrich, S.; Morewood, R.; Maxwell, M. J.; Huber, T; Nitsche, C.; Goldfarb, D.; Otting, G;
“Site-selective generation of lanthanoid binding sites on proteins using 4-fluoro-2,6-dicyanopyridine”
Magn. Reson., 2022, 3, 169–182.
5.
Ullrich, S.; George, J.; Coram, A. E.; Morewood, R.; Nitsche, C;
“Biocompatible and selective generation of bicyclic peptides”
Angew. Chem. Int. Ed., 2022, 61, e202208400.
4.
Johansen-Leete, J.; Ullrich, S.; Fry, S. E.; Frkic, R.; Bedding, M. J.; Aggarwal, A.; Ashhurst, A. S.; Ekanayake, K. B.; Mahawaththa, M. C.; Sasi, V. M.; Luedtke, S.; Ford, D. J.; O’Donoghue, A. J.; Passioura, T.; Larance, M.; Otting, G.; Turville, S.; Jackson, C. J.; Nitsche, C.; Payne, R. J;
“Antiviral cyclic peptides targeting the main protease of SARS-CoV-2”
Chem. Sci., 2022, 13, 3826–3836.
3.
Ullrich, S.; Ekanayake, K. B.; Otting, G.; Nitsche, C;
“Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir”
Bioorg. Med. Chem. Lett., 2022, 62, 128629.
2.
Ullrich, S.; Sasi, V. M.; Mahawaththa, M. C., Ekanayake, K. B.; Morewood, R.; George, J.; Shuttleworth, L.; Zhang, X.; Whitefield, C.; Otting, G.; Jackson, C.; Nitsche, C;
“Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors”
Bioorg. Med. Chem. Lett., 2021, 50, 128333.
1.
Ullrich, S.; Nitsche, C;
“The SARS-CoV-2 main protease as drug target”
Bioorg. Med. Chem. Lett., 2020, 30, 127377.